Showing posts with label Scientist's Conclusion. Show all posts
Showing posts with label Scientist's Conclusion. Show all posts

Wednesday, February 20, 2013

A Scientist's Conclusion - Part 7

This is the final installment of this story. If you'd like to read it from the beginning, you can start here and move through the links to this one.
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Sung was not in the hallway when the committee left the room, and he was not in the Men's Room where Carl stopped on the way back to his office. Carl was almost relieved that Sung was not waiting in the office when he got there, because he really didn't want to face the student. Carl was annoyed by the prospect of having to spend another year or more working with Sung on a Master's thesis, checking on him constantly to be certain that he was performing adequate controls, organizing his data, correcting the grammar and sentence structure of his thesis, and then having to sit through a thesis defense with the very real possibility that Sung would perform as miserably on that examination as he had done on this one.

Carl stayed in his office late that evening, as usual. He tried to dissociate himself from his student's failure by working on a theoretical paper that was his secret pride and that had been put aside during Sung's exam preparation. The sun had set and the office window that looked out on the silent, surrounding darkness mirrored Carl's silent, intense activity at his desk, cluttered with references and old notes for the paper.

Caught in thought, he glanced up at the blackened window and saw an image there—surreal—as if standing suspended in mid-air, three stories above the ground. Carl wheeled around in his chair. He faced a figure standing, feet on the floor, in the fully lighted room.

"Sung!" Carl exclaimed with a start. "When did you come in? How long have you been standing there ?"

Sung didn't answer. He stood motionless, his hands in his pockets and his eyes on the floor. He glanced up at Carl for a moment, then lowered his eyes and focused on a spot near Carl's feet. Sung stood there impassively; his face, uncharacteristically elongate for an Asian, was expressionless. His eyebrows extended across his forehead in two straight ridges and his mouth was set in a straight, firm line, parallel to the brows. The flesh around his eyes seemed puffy and, despite high cheekbones, his eyes had darkened circles under them. Sung seemed suddenly strange to Carl, very strange, as if he were someone Carl had never met before, as if the scientist were seeing the student for the first time.

"We have to talk about your exam, today," said Carl, bringing up the subject neither he nor Sung wanted to talk about. "You know you did very poorly on the exam."

"Questions not good. You do not advise me correctly on questions," retorted Sung with a slightly belligerent tone.

"Well, there's no way to know for sure what people are going to ask," said Carl defensively. "You just have to be prepared and then think on your feet. You are going to have to learn how to think on your feet."

"When will I take next examination?"

"You won't. You failed the exam, but you're lucky the committee didn't just decide to fail you outright. They recommended that you be allowed to finish at the Master's level."

"But I want to take Doctor's degree."

"I know that, but you flunked the examination. You'll have to settle for a Master's degree. Even that won't necessarily be easy."

"If I take Master's degree, then I must take Doctor's degree again. How long to do that?"

"Sung, you don't have that option. Not in this department, at least. You were recommended for a terminal Master's degree and that's final."

"You give me bad advice," said Sung with a tone more hostile than Carl had heard him use before.

With that, Sung moved slightly backwards and pulled one hand out of his pocket. In the hand was a gun.

"Sung, for God's sake!"

Carl was paralyzed. His mind whirled back over all his interactions with this student, trying to find a key, a clue, that might have allowed him to foresee such a catastrophic eventuality. Nothing. He came up with only a series of missed communica­tions, but nothing that could have presaged this. What signs had he missed that could have warned him of this danger? The man was clearly mad. Why had he not seen that?  What about his own future?  What about his theory of hydrophobic interactions that was to be his lasting contribution to an understanding of organic macromolecules? What about his wife and their two-year-old son? What about his parents who expected so much of him? What about those childhood playmates who had once taunted him, to whom he had intended to prove himself undeniably superior?  How had his pursuit of truth betrayed him so utterly? How was it possible for reality to be so irrational?

"No, Sung, please."

Sung stood there, still, as if eternal. Then Carl heard a click, followed quickly by a crack of the gun that echoed blackly, a split second later, in his skull.

 

Wednesday, January 30, 2013

A Scientist's Conclusion, Part 4


As the time for Sung's comprehensive exam drew near, Carl still doubted that Sung was, in fact, prepared, that he could ever be prepared to stand that examination and do it justice. Even in their weekly sessions, Sung hesitated to complete answers and usually refused to pursue a line of reasoning without receiving a nod of affirmation, or an authoritative "Go ahead." from Carl. Carl mused to himself, half­ seriously, that he might be able to nod Sung through some of the more difficult questions on the oral exam if the student could only get himself off to a correct start.
The week of comprehensives came and Sung passed the general written exam—not brilliantly but adequately. His specialty written exam was uneven; he had badly botched one of the three questions on that exam. Because of his performance, he had been given a borderline pass. Thus, the issue of whether he passed or failed, and, hence, whether or not he could continue his pursuit of the Ph.D. degree, hung upon the oral exam. His committee was composed of four individuals in addition to Carl: Drs. James Karesh and Otto Munster from the Biochemistry Department, Dr. Harris Stillwell from Pathology, and Dr. Anando Vanadian from Immunology. Carl was very proud of having gathered this committee for his first graduate student; they were among the best minds and greatest reputations at the institution. Their willingness to serve on this committee was taken by Carl, perhaps with some justification, as an indication that he was accorded a certain esteem as a scientist, despite the fact that he had not yet achieved national recognition.
The format of the oral exam was structured so that the student first gave an overview of his thesis project, including highlights of any preliminary data he might have obtained. Then the committee members were free to question the student on any material to which he could reasonably be expected to have been exposed during his course work and his literature search pertaining to the thesis topic. In practice, the examination usually began with questions centering around the candidate's thesis project, then ranged farther afield as answers to questions suggested new questions to the examiners. A successful exam was usually fairly brief, perhaps an hour and a half, whereas less successful exams often went on for three or four hours.
Carl had rehearsed Sung twice on his presentation and, after each rehearsal, had asked Sung several questions of the type that might logically relate to the presenta­tion. Carl had also scheduled the examination for the afternoon at 2:00 P.M., for two reasons. First, he hoped that the committee would be in a pleasant, ruminative mood after lunch, and secondly, he hoped that, since the exam was to begin fairly late in the day, it might not last for more than two or three hours and Sung might be spared some of the more probing and esoteric questions that often come at the end of a long examination.
The afternoon of the examination, two others were present in the seminar room in addition to Sung's committee: the departmental graduate advisor, Dr. William Bock, and the department chairman, Dr. Henry Davidson. Carl was not entirely surprised, since it was quite within accepted procedure for any member of the department to be present at the oral examination of any departmental student. Nonetheless, their presence made Carl uneasy.

The next installment is  here .

Wednesday, January 16, 2013

A Scientist's Conclusion, Part 2

(continued from part-1.html)

It was with the realization that Sung Lee did not, in fact, understand the importance (or even the purpose) of controls that Carl came to appreciate the enormity of the undertaking to which he had committed himself. That realization came about after Carl's suggestion that a drug effect on Sung's tumor-cell line might have been caused by increased cell membrane permeability or by increased levels of a calcium-binding protein in the cells as a consequence of the drug treatment.

Sung Lee thereupon went to the library to find methods to assay those parameters. After more than three weeks of hard work and experimentation, Sung came triumphantly into Carl's office with the announcement that Carl had been right on both accounts. Carl asked the obvious questions concerning the time-course and dose-dependence of the effect, and it was clear that Sung had either not considered these questions, or else he did not have the courage to say: "These are just preliminary data." It was as if Sung expected Carl to be so pleased at being told that his ideas were correct that the methodology would not be questioned. Then Carl, in what he thought was an inquisitive (not inquisitorial) tone, asked Sung:

"Why do you think your data show increased calcium-binding protein in the cells rather than increased binding of calcium to the protein that's already there?"

"No, calcium-bind protein increase," said Sung emphatically.

"How could you determine that it was increased protein rather than increased affinity?"

"Everybody say so.  Anderson do same experiment on amoebae and say calcium partition coefficient directly proportional to amount of calcium-bind protein."

"Yes, but that's in a non-permuted system. Let me see your data."

Sung hesitantly gave him some graphs and Carl asked for the counter tapes. He noticed that, on the first tape he looked at, the counts were all quite similar.

"What counts are these?"  Carl asked.

"They calcium counts from drug-treated cells," said Sung proudly.

"Where are the controls?" asked Carl.

"Controls in other experiment," explained Sung.       

"What do you mean, other experiment?" Carl's voice rose through incredulity to anger. "You don't know a God-damned thing if you don't run controls with every single experiment! For Christ's sake, what do you think a control is for, anyway? Do you have any idea?"

Sung was mute--stunned.  There was nothing in his background, nothing in his training, nothing in his cultural heritage that had prepared him for this outraged outburst by one who was supposed to be his guide and protector.

"Well...I asked you, what do you think a control is for?" demanded Carl, impatiently.

Confused, ashamed, and unable to understand why such an apparently trivial matter assumed such importance for his mentor, Sung answered, "I don't know."

"Oh, for God's sake. Come back to my office at two o'clock tomorrow afternoon and we'll talk about controls." Carl didn't have the mental energy to deal with the subject at that moment, and he also knew that Sung had become so alarmed and defensive that any further discussion of the matter at the time would be futile.

In the interim, Carl confided to some colleagues that he had serious doubts about Sung's ability to do the work necessary for a Ph.D. degree and, more importantly, he wondered whether or not Sung had the mind to be a scientist at all. One of the colleagues in whom Carl confided was the departmental graduate advisor, Dr. William Bock. Dr. Bock suggested that Carl postpone Sung's comprehensives until the next scheduled exam, which was six months hence.

The next installment of this story is here.